Release date: 2014-07-08
Recently, in a research paper published in the international magazine PLoS Computational Biology, researchers from the Australian National University have provided new ideas and evidence for the development of new pain therapy by studying the specific mechanism of action of pain relief drugs.
Researcher Ben Corry said that in this study we developed a new computer model that first revealed how the local anesthetic drug benzocaine and the antiepileptic drug phenytoin enter nerve cells to suppress the transmission of pain signals to the brain; By understanding the mechanisms of action of a range of drugs, researchers can design a new generation of drugs for chronic pain, epilepsy, and arrhythmias.
The molecular mechanism that reveals the adsorption of drug molecules onto nerve cell proteins is very helpful in designing new non-side-effect drugs to treat human diseases; the design of local anesthetics is inspired by cocaine, and cocaine has been used in the human world. It has been more than 100 years, but its specific role in the body is not clear.
When the protein molecule that plays the small channel of the nerve cell is opened, the pain signal is transmitted to the brain, allowing sodium and potassium ions to pass. This stimulation indicates that the final binding site of the drug is in the sodium ion. Gated inside the protein, which also inhibits the transmission of pain signals to the brain; drugs that block sodium channels can also be used to treat neuronal-related disorders such as epilepsy and arrhythmias, but currently targeting sodium channels The drug will run through the body and cause certain side effects.
Researchers say that pharmaceutical companies are particularly interested in developing new drugs that target specific proteins in specific parts of the body. Understanding the molecular mechanisms of these drugs will also help the development of a new generation of drugs, chronic Pain therapy is a larger market, and researchers hope to develop more effective pain-relieving drugs through in-depth research in the future.
Source: Bio Valley
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