2017 will be an extraordinary year in the CAR-T field. First, this new immunotherapy strategy, which transforms patients' live T cells into a fierce tumor killing tool, is expected to be officially approved by the US FDA, including Kite Pharma's treatment for non-Hodgkin. KTE-C19 of lymphoma, and CTL019 of Novartis for the treatment of childhood B-cell acute lymphoblastic leukemia. Juno (Juno), one of the three giants of the CD19-CAR-T, was put on hold due to the death of the JCAR015.
In terms of CAR-T treatment of solid tumors, some early clinical data are expected to be reported in 2017, such as CAR-T treatment data for lung cancer, breast cancer, rectal cancer, and other solid tumors. However, much different from blood tumors, because the targets suitable for solid tumor CAR-T are very limited, and these targets are often expressed on healthy tissues, resulting in the attack of CAR-T cells on normal cells. Therefore, safety in the CAR-T treatment for solid tumors will become the most worrying place in the industry.
However, another highlight that attracted the most attention in 2017 should belong to Cellectis' UCART19. Unlike the above companies, UCART19 does not use the patient's own T cells for transformation, but is genetically edited to knock out a healthy human-based donor T cell after TCR, so it can be batched. Production of products. The French company hopes to build a pool of allogeneic CAR-T cells to accommodate any patient in need. Two clinical trials have been conducted in UCART19, and two British infants tested have been relieved.
Natural Field cosmetics raw material extracted from plants contain highly-pure and standardized active substances. They are mainly used to improve skin and hair health and appearance. The strong ingredients are: 5-Aminolevulinic acid, Idebenone, Chlorogenic acid, Polydatin. Etc.
Cosmetics are natural, synthetic or extracted various effects of different substances as raw materials, heating, stirring and emulsification and other production processes from the chemical mixture. It is a compound mixture of various raw materials after reasonable mixing and processing. The raw materials of cosmetics are various in variety and performance. According to the properties and USES of cosmetic materials, they can be divided into two categories: matrix materials and auxiliary materials.
The former is a kind of main raw material of cosmetics, which occupies a large proportion in the cosmetics formula and plays a major role in the cosmetics. The latter plays a role in shaping, stabilizing, or imparting color, fragrance, and other properties to cosmetics, which are not used in large amounts in cosmetic formulations but are extremely important.
Skin Whitening,anti-aging,arbutin,kojic acid,fullerenes
PYSON Co. ,Ltd. , https://www.pysonbio.com