Honeysuckle medicine (poison) science

Drug (poison) science

Honeysuckle water extract gavage, no significant toxic reactions to rabbits, dogs, etc., have no effect on respiration, blood pressure, urine output. The LD50 of subcutaneous injection of this product was 53 g/kg. Chlorogenic acid has a priming effect and can cause allergic reactions, but this reaction is not given orally, since chlorogenic acid can be converted into a substance with no allergenic activity for intestinal secretion. The hemolysis test results showed that 0.1 to 0.5 mL of steamed products were all free of hemolysis within 3 hours; 0.1 to 0.5 mL of dried products appeared hemolysis immediately after dosing; 0.1 to 0.5 mL of Guizhou Yinhua flowers were within 3 hours. No hemolysis phenomenon; Henan honeysuckle pH6.0 when 0.1 ~ 0.3mL no hemolysis; Shandong honeysuckle: 0.1 ~ 0.5mL no hemolysis in 3 hours. The order of LD50 of the five materials is: honeysuckle, honeysuckle, steamed product, Guizhou commodity, honeysuckle sun dried goods without hemolysis, and sun-dried, hemolytic. Therefore, it must be used as a raw material for injection. Steaming products. [11]

1. Effect of anti-pathogenic microorganisms: In vitro experiments showed that flowers and vines are common to various pathogenic bacteria such as Staphylococcus aureus, hemolytic streptococci, Escherichia coli, dysentery bacilli, Vibrio cholerae, typhoid bacillus, paratyphoid bacillus and so on. It has a certain inhibitory effect and it is also effective against pneumococcus, meningococcus, Pseudomonas aeruginosa and Mycobacterium tuberculosis. The water infusion has a stronger effect than the decoction, and the leaf decoction has a stronger effect than the flower decoction. If combined with Forsythia, antibacterial range can also be complementary; combined with penicillin can enhance the antibacterial effect of penicillin on resistant Staphylococcus aureus, which may be a synergistic effect in the inhibition of protein synthesis in vivo.

2, anti-inflammatory and antipyretic effects: intraperitoneal injection of honeysuckle extract 0.25g/kg, can inhibit the rat carrageenan leg swelling. Another report that honeysuckle injection 30 ~ 40g/kg can reduce egg white sex foot swelling. Intraperitoneal injection of honeysuckle extract 8g/kg, 2 times / day, for 6 consecutive days, the croton oil granulocyst in rats, there is also significant anti-bleeding and anti-proliferative effect. Early reports that honeysuckle has a significant antipyretic effect, but with the cholera vaccine, potato bacillus, subtilisin, etc. to the rabbit ear vein injection, fever, has not confirmed that honeysuckle decoction 5g/kg intragastric antipyretic effect that this It may be related to different honeysuckle preparations, doses, or tolerability of rabbits.

3, to strengthen the immune function: honeysuckle decoction diluted to 1:1280 concentration, can still promote leukocyte phagocytosis. Intraperitoneal injection of honeysuckle injection also significantly promoted the phagocytic function of inflammatory cells.

4, the central stimulant: by electric shock, transfer cage and other experimental methods to prove that oral chlorogenic acid, can cause rats, mice and other animals central nervous system excitement, the role of the intensity of caffeine for the 1/6, 2 The combination of non-adding and enhancing effect.

5, lipid-lowering effect: rat oral honeysuckle 2.5g/kg can reduce intestinal cholesterol absorption, lower plasma cholesterol levels. In vitro experiments also found that honeysuckle can be combined with cholesterol, but Simiao Yongan Decoction (Honeysuckle, Scrophularia, Angelica, Licorice) was used to treat experimental atherosclerosis in rabbits. No hypolipidemic and aortic wall cholesterol levels were observed.

6. Anti-endotoxin: The endotoxin content was determined by the limulus test method. 300% honeysuckle (Lonicera) injection was diluted 1:2 to 1:64. In vitro tests were significantly reduced in the test solution by either the concave or the tube method. The endotoxin content of the 1:2 to 1:8 dilution tube was the same as that of the negative control tube, and the positive control was gel-like. Honeysuckle (Lonicera) distillate 6g/kg intravenous injection of Pseudomonas aeruginosa poisoning each other 2.8mg/kg intravenous injection of rabbits caused by temperature decline and white blood cell count have a confrontational effect, honeysuckle (Lonicera) distillate 7.5g/kg or injection 2.5g/kg intraperitoneal injection of the liquid, Pseudomonas aeruginosa endotoxin 65mg/kg intraperitoneal injection of mice have a protective effect, reduce the mortality of mice.

7. Other effects: There have been in vitro screening experiments with water and wine extracts of honeysuckle having significant cytotoxic effects on sarcoma 180 and Ehrlich ascites carcinoma. The honeysuckle extract has a mild preventive effect on experimental gastric ulcers in rats. Oral high-dose chlorogenic acid can increase gastrointestinal motility and promote secretion of gastric juice and bile. Chlorogenic acid and its breakdown products have excitatory effects on isolated rat uterus. In addition, chlorogenic acid slightly increased the pressor effect of epinephrine and its norepinephrine on cats and rats, but had no effect on the cat's nictitating membrane response.

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Specifications

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