Release date: 2014-08-07
Breast cancer has not been a woman's patent. It is estimated that in 2013, 2,240 men in the United States developed invasive breast cancer (the main type of breast cancer), resulting in 410 deaths. In general, male breast cancer (MBCs) usually have larger tumors and are more susceptible to invasion of the lymphatic system than women.
Recently, Natalie Swergold of the Saint George's University School of Medicine in Grenada has reviewed the relevant literature to provide screening recommendations for high-risk groups. The article was published in the scientific journal "Surgical Science" (surgery) ) Published in July 2014.
The authors searched for a comprehensive literature between 1982 and 2013, with a special focus on genetics, epidemiological risk factors, and MBC screening. Search keywords include "male breast cancer risk factors", "male breast cancer epidemiology", "male breast cancer genetics", involving 34 studies, 4865819 patients.
Five studies (N=327667) focused on a family history of breast cancer as a risk factor for male breast cancer. 15%-20% of breast cancer men have a family history of breast or ovarian cancer, and first-degree relatives in family history with breast or ovarian cancer increase the risk of breast cancer in men by 2-3 times.
Seventeen studies (N=5451) analyzed the association between several genetic genes and male breast cancer. The risk of BRCA1 mutation carriers was 1%-5% in males, while the risk of BRCA2 mutation carriers was more The association between male breast cancer and PALB2, androgen receptor gene, CYP17, and CHEK2 is still unclear.
Five studies (N=16667) investigated occupational risk factors associated with male breast cancer, and men who worked in the cosmetics and automotive industries increased their risk of breast cancer by eight times.
Eleven studies (N=4843598) analyzed risk factors for estrogen-specific abnormalities and male breast cancer, including oligospermia (relative risk, RR=29.64), obesity (RR=1.98), orchitis or epididymitis ( RR = 1.84) and male breast disease (RR = 5.86) both increased the risk of breast cancer in men.
In summary, routine screening for male breast cancer should consider all high-risk male populations, including those with a history of breast cancer, a family history (defined as a mother or sister), a BRCA2 mutation (regardless of family history), and a diagnosis of fine tubules. Men with dysplasia, chemical or motor vehicle industry. All male breast cancer patients should be recommended for BRCA2 gene testing. Increasing public and physician education must raise awareness of this rare disease and the need to screen for high-risk groups.
Source: Irvine Reading
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