XFp cell energy metabolism detection system
As a miniaturization platform for gold standards, the XFp Cell Energy Metabolism Detection System is the first to transplant extracellular flow detection technology to a platform that is more suitable for use in a small sample of individual laboratories, and adhering to the consistent high level of detection results, which will be currently hot. Energy metabolism testing brings more laboratories at all levels. This novel system has also been named one of the top ten innovative products in life sciences in 2014.
With the development of medicine, genomics and proteomics, we gradually realize that there is a close relationship between bioenergy and many diseases. Cancer, cardiovascular disease, diabetes, obesity, neurodegenerative diseases, aging, and various drug toxicological mechanisms are all related to the supply and demand of energy.
US Seahorse Bioscience has a number of patents for simultaneous detection of multiple physiological indicators of cells. The XF cell energy metabolism detection system uses high-sensitivity micro-sensors and the pioneering detection principle to revolutionize real-time, high-throughput, multi-sample sources without destroying samples, invading cells, and without biohazard conditions. Detection of cellular mitochondrial respiration and glycolysis. The baseline value of respiratory level, ATP production ability, proton leakage level, maximum respiratory capacity, respiratory capacity reserve, glycolysis level, maximum glycolysis capacity, and glycolysis reserve value of the sample can be obtained in one experiment. The detection value of the main indicators of cell metabolism, and the change of the cell bioenergy. Real-time comparison of these two energy generation pathways reveals dynamic interactions between them.
Since 2006, the XF cell energy metabolism analysis system has installed nearly 1,000 units worldwide, and the cumulative literature has been published in more than 1,200 articles. About 20% of the literature has been published in top international journals such as Nature, Cell, EMBO, and PNAS. . As a gold standard for cell energy metabolism research, this device is recognized and welcomed by academic authorities and scientists around the world.
working principle:
The XFp cell energy metabolism detection system uses an 8-well microplate as a platform to simultaneously detect mitochondrial respiration and glycolysis in cells. Mainly by detecting changes in metabolic indicators in cells, such as ECAR (extracellular acidification rate) and OCR (oxygen consumption rate), and then analyzing mitochondrial function, to understand the true meaning of metabolic changes or to make drug toxicity evaluation. The detection is fast, flexible, and sensitive, and can be widely used in various fields of basic research.
Product advantages:
• Rapid detection of small amounts of sample • Run standard tests without the need for specialized metabolic research experience.
• Higher price/performance ratio
main application:
The functional metabolic parameters provided by XF technology have become the gold standard for energy metabolism. The technology is used in a wide range of applications, including cancer, cardiovascular disease, cell physiology, aging, immunology, neurodegenerative diseases, obesity, diabetes, metabolic disorders, stem cell biology, toxicology and liver biology, translational medicine, microbiology, Drug screening and safety evaluation.
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