Researchers at the University of Lincoln in the United Kingdom have synthesized an antibiotic that kills "superbugs" and cures bacterial infections in experimental mice. The research paper is published in the latest issue of the Journal of Medical Chemistry.
The antibiotic, called Teixobactin, was discovered in the soil by American scientists in 2015 and is the first new antibiotic in the last 30 years to kill methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). ) Deadly super bacteria, etc., will not induce bacterial resistance. Some research groups are dedicated to the chemical synthesis of Teixobactin, hoping to develop a new generation of antibiotics.
Researchers at the University of Lincoln replaced key amino acids at specific points in the structure of Teixobactin, making it easy to replicate. The researchers found that the simplified synthetic Teixobactin is highly effective in dealing with super bacteria in test tubes. Subsequently, the Singapore Eye Institute successfully cured the bacterial infection of the experimental mice with this synthetic antibiotic. This synthetic antibiotic not only cures the infection, but also minimizes the symptoms of infection. The control drug moxifloxacin does not have this effect.
Ishwal Singer, a specialist in drug design and development at the University of Lincoln School of Pharmacy, told the University of Lincoln website: "The success of translating our success in this simplified version of the test tube into actual cases is a huge breakthrough in the development of new antibiotics. We are closer to developing a simplified version of Teixobactin with therapeutic potential."
The problem of bacterial resistance is becoming more and more serious, and bacteria resistant to various antibiotics are called super bacteria. Experts warn that by 2050, bacterial resistance can cause 10 million deaths a year. Developing new antibiotics may be the last resort to solve this problem. (Xinhua)
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