Under the support of the national key research and development program “Protein machinery and life process regulationâ€, “The functional mechanism of protein machinery in the process of infection and pathogenesis of important pathogensâ€, the Gebaoxue team of Tongji University and Mao Zhiyong team cooperated to discover DNA repair. A new mechanism for regulation with tumors.
Genomic DNA faces a variety of injuries, and damage that cannot be repaired in time can lead to tumorigenesis. Cyclic guanosine monophosphate-adenylate synthase (cGAS) is a DNA recognition receptor that recognizes pathogenic microorganisms and self-DNA in the human cytoplasm and activates immune responses. The physiological process of cGAS is only studied in the cytoplasm, and it is not clear whether it enters the nucleus directly involved in DNA damage repair.
For the first time, the team discovered that cGAS can transfer from the cytoplasm to the nucleus after DNA damage, and one of the main repair methods for inhibiting DNA double-strand break repair, homologous recombination repair, leads to genomic instability and ultimately promotes tumorigenesis. And development. This study, for the first time, systematically elucidates the new functions of cGAS in the nucleus completely independent of DNA recognition function. It not only pushes the functional research of cGAS into a new field, but also finds an important target in the development of anti-tumor drugs. The theoretical basis for the development of new anti-tumor drugs based on the intervention of cGAS into the nucleus. Related results were recently published in the journal Nature.
Source: Ministry of Science and Technology
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