The first male unique anti-leukemia gene appeared
May 10, 2018 Source: Science and Technology Daily
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];According to a recent report by the British "Independent" official website, British scientists discovered the first gene UTY that only appears in males. Researchers say that studies in humans and experimental mice have shown that UTY can help humans fight a variety of cancers, including leukemia. This study will change people's understanding of the Y chromosome and may lead to new acute myeloid leukemia (AML) therapy.
Women have two X chromosomes, while men have one X chromosome and one Y chromosome. The X and Y chromosomes share many genes, but only a few genes (including UTY) are found only on the Y chromosome. Scientists have long believed that the Y chromosome carries only genetic information that causes the embryo to develop into a male rather than a female.
Researchers at the Wellcome Sanger Institute and the University of Cambridge wrote in the latest issue of Nature Genetics that UTY seems to offer an extra layer of protection against AML.
They studied the X chromosome gene UTX in humans and mice, trying to understand what role they play in AML. It was found that loss of UTX accelerates the progression of AML because healthy UTX genes play a key role in coordinating cellular protein and gene expression. They also found that UTY protects male mice lacking UTX against AML deterioration because it can perform the role of UTX in preventing cell madness. Moreover, the anti-cancer effect of UTY is also effective against several other human cancers.
The main author of the paper, Dr. Marzzezta Gzdadka of the Sanger Institute, said: "Previously, the only function of the Y chromosome was to create male sexual characteristics, but our research shows that the Y chromosome can also fight. AML and other cancers."
The researchers say that the current survival rate of AML patients is still very low, the new study will help scientists to more comprehensively understand the genetics of AML onset and deterioration, understanding this process is crucial for the development of targeted drugs for AML. (Reporter Liu Xia)
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