Secretly decides what is the reason for the drinker

Recently, media reports said that a young man in Hangzhou had slept half a catty of white wine for the first night. He stalked because of accidental suffocation. He did not wake up the next day. As a result, the topic of the Year-end Wine Bureau and the amount of drinks caused heated debate among users. The doctor of the Sichuan Provincial People's Hospital stated that how a person's drink is determined entirely by genes does not have much to do with acquired practice.

Question: Why is the amount of alcohol per day still a cup

Mr. Liu, 27 years old, is from Luzhou, Sichuan. After graduating from university, he entered a computer company in Shiqiaopu to sell. “If you want to earn more, you have to drink more.” Under the influence of the wine table culture, Xiao Liu wanted to increase the amount of alcohol from the beginning of the work. The grandfather who worked for many years at the winery in Zhangzhou told him that as long as he drank a little bit each day, gradually Increase the amount of alcohol will increase. In the past year, Xiao Liu had to drink some red wine every day while returning home. However, he still cannot change the state of “the couple will blush and a cup will fall”. He did not understand why he grew up on the side of the jar. Why can't he drink it?

Drinking genes determine drinkers

For a long time, people have always believed that drinking is practiced. In December last year, a study by the United States "Provincial Academy of Sciences" showed that: The amount of alcohol and whether or not there is alcohol addiction, not cultivated after birth, but by the "drinking genes" determined. This gene can influence people's reaction to alcohol and thus determine whether this person is an alcoholic.

First, they developed a mouse that loves wine over drinking water, proving that the drinking habits are heritable and genetically determined; then, they designed the “alcohol challenge” and asked more than 300 subjects to be 8 Drink a 20% alcohol solution in minutes. After drinking, they also need to fill out a form to record their feelings; a special instrument is also used to measure the degree of post-alcoholic shake and indicate the subject’s degree of intoxication.

Researcher Raymond L. White found that some genes on chromosome 15 are closely related to the degree of intoxication. This drinking gene is a group of genes at work, after a complex process of change, affecting people's reaction to alcohol. Interestingly, drinking genes can be inherited from generation to generation. In other words, Dad can drink a pound, and his son can't miss it. For some people, this is undoubtedly a good news - it is possible to prevent the emergence of "addicts". Perhaps in the future, drinking genes can provide scientists with ideas to invent new drugs that change drinking genes and help people stop drinking.

People who drink blush not only don’t drink much, but they are more likely to suffer from esophageal cancer than those who don’t blush. Drinkers couldn’t practice it. If dad could drink a pound, his son would not be less than 82; Medicine, there has never been a truly effective hangover method in this world.

Argument: The alcohol gene will not change for life

What is an alcohol gene? Simply put, it is a series of genes involved in the decomposition of alcohol, including alcohol dehydrogenase, acetaldehyde dehydrogenase, superoxide dismutase, and peroxidase, which determine the difference in response between different people drinking alcohol. One of the most directly affected genes is aldehyde dehydrogenase (ALDH2). If abnormal occurs, acetaldehyde will accumulate in the body and cause serious damage to the liver.

Dr. Luo Fukang, an attending physician at a hospital’s laboratory, explained that the alcohol gene is a segment of the human gene sequence. When a person is born, the alcohol gene has already determined the size of his drink and will not change for life. The alcohol gene test carried out by the hospital is based on the analysis of genotypes corresponding to acetaldehyde dehydrogenase to analyze the strength of a person's ability to metabolize alcohol to determine whether it is suitable for drinking.

He introduced that the human ALDH2 is mainly divided into three types, that is, homozygous wild-type, heterozygous mutant, homozygous mutant, respectively, representing the strength of three different alcohol metabolism, detection of only one type will be presented Positive, reflecting the tester's corresponding ability to hang up. Among them, the homozygous wild type has a good hangover ability, the heterozygous mutant type is poor, and the homozygous mutant type is very poor.

Dr Luo said that Xiao Liu's test results showed that the homozygous mutant alcohol gene showed positive, indicating that the hangover enzyme had no activity at all and had very poor alcohol metabolism. At the time of birth, the alcohol gene has already determined the size of the drink and will not change for the rest of its life. It is useless to practice alcohol.

Two folk arguments

Can Northerners Drink More Than Southerners?

Can Europeans and Europeans drink more than Asians?

Answer: ×

"Because of the forthright character, we are able to drink more than the southerners." At the various wine tables, the Northerners' words of superiority have caused many small debates among friends.

"This is not necessarily the same from the genetic point of view, the potential for southerners and northerners to drink should be the same." Dr. Luo Fukang said that studies have shown that due to the integration of thousands of years of ethnic people, northerners acetaldehyde off The probability of hydrogenase mutation is somewhat lower than that of southerners. This is because acetaldehyde dehydrogenase is an enzyme that can induce secretion. Long-term drinking can promote more secretion in cold or humid areas. Therefore, in the case of normal enzyme activity, living habits become the first reason to determine the amount of alcohol.

Can Europeans and Europeans drink more than Asians?

Answer: √

China is the country with the largest number of people in the world. The wine culture is extensive and profound. The research report shows that from a genetic analysis, Asians are the most unethical race in the world.

Dr. Luo Fukang said that there are indeed ethnic differences in genes. Compared with Chinese people in Europe, Caucasians, Americans, and African Americans, the probability of acetaldehyde dehydrogenase mutation is very small. Therefore, most alcohols can be metabolized smoothly. Therefore, people in Europe and America can drink without having to envy. It's just a genetic difference.

Two views of folk

Can someone who drinks blush drink?

Answer: ×

In folk opinion, there is a saying that people who drink blush are more suitable for drinking, but in fact the opposite is true.

Dr. Luo Fukang said that the more red the face is, the more acetaldehyde accumulates, resulting in blood vessel expansion. This shows that the alcohol dehydrogenase (ADH) is normal and the aldehyde dehydrogenase (ALDH) is lacking. The phenomenon of dizziness and nausea vomiting of such people is obvious.

Can people who drink white face drink?

Answer: ×

Dr. Luo Fukang said that if the face is white after drinking, it would be even more scary, indicating that these people lack of alcohol dehydrogenase, even the basic alcohol is very difficult to quickly decompose, resulting in alcohol accumulation, blood oxygen carrying capacity, face so More and more white.

He reminded that such people often do not know their own bottom line. Other people also think that they can drink. If they are not restrained, they are prone to acute alcoholism.

ALDH2 (Acetaldehyde Dehydrogenase)

Genotype positive result hangover ability

Homozygous wild-type metabolic ability, high activity (can be moderate drinking)

Heterozygous mutants are poorly metabolized and only partially active (drinking control required)

Homozygous mutants are poorly metabolized and completely inactive (preferably not drinking)

Drunken and drug-solvable?

Medically, drunkenness is called alcoholic poisoning. After the drunken drunkenness, many people have eloquently told you some special tips for drunkenness: drinking strong tea, taking liver-protection medicine, eating bananas, and drinking plenty of water.

Unfortunately, there is no scientific evidence that these methods are useful, and some are even detrimental to health. Earlier this year, Rachel Freeman of Indiana University School of Medicine told people in the British Medical Journal. As early as 2005, the United Kingdom and the Netherlands have verified common hangover methods through experiments. These methods include 3 drugs, 4 food therapies, and fructose hangover. The results showed that these methods have a certain effect on relieving certain symptoms (such as nausea and headache) after drunkenness, but they cannot relieve drunkenness. In other words, there is no good way to drunk and it is almost impossible to find an effective hangover method that suits you.

At present, there are many drugs that fight the name of hangover. The bridegroom on the wedding feast and the regulars at night club CLUB may have used it. Annoyingly, there is no real hangover drug in medicine. The puffing effect is actually a psychological hint to the drinker - it is not easy to get drunk when you are learning about alcoholic drugs. Even drinking three or five cups will feel good. In other words, the effect of hangover drugs is mostly placebo. The ingredients of hangover drugs are mostly amino acids, vitamins and various enzymes, which can relieve headaches and nausea at most. They will never double their drinking capacity and they will not be drunk.

Food flavoring

Tartaric Acid, Vanillin, Menthol, Menthol Crystal, Flavoring agent, Baking powder

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