Release date: 2014-12-30
Patients with rheumatoid arthritis (RA) have elevated insulin resistance (IR), but elevated insulin resistance in these patients is not associated with an increased risk of atherosclerosis, and the study is published in Arthritis & Rheumatology.
Jon T. Giles of Columbia University, MD and colleagues compared IR between 95 RA patients and 98 non-RA controls, and used HOMA insulin resistance (HOMA-IR) index to assess insulin resistance. HOMA-IR Steady state model insulin resistance index.
The researchers found that the mean HOMA-IR level was 31% higher in the RA group. In the control group, HOMA-IR was associated with C-reactive protein and interleukin-6 levels, but this association was weaker in the RA group. .
In those patients with rheumatoid arthritis, elevated HOMA-IR is associated with positive rheumatoid factor in men and women, and in women with prednisone. At an average of 3.2 years of follow-up, neither baseline nor mean HOMA-IR was associated with an increased risk of atherosclerosis between RA patients. Although RA has a higher IR than non-RA, higher levels of IR may not increase the risk of atherosclerosis alone.
Source: Bio Valley
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