Japanese research on new treatments for Alzheimer's disease

Medical Network November 24, researchers at Kyoto University in Japan have found new ways to reduce the pathogenic substances of Alzheimer's disease in the latest research using human induced pluripotent stem cells (iPS cells).

Memory impairment is one of the main symptoms of Alzheimer's disease, a disease is considered to be related to Î²- amyloid deposition in the brain over.

The iPS Cell Research Institute of Kyoto University announced that it has used iC cells from 13 volunteers, including 5 familial Alzheimer's patients and 4 sporadic Alzheimer's disease without a family history. Patient and 4 healthy volunteers. The researchers allowed these iPS cells to differentiate into nerve tissue with symptoms of Alzheimer's disease in the laboratory, and then tested them with 1,258 drugs.

The test found that the dopamine receptor agonist bromocriptine used to treat Parkinson's disease, sodium cromolyn for the treatment of asthma, and topiramate for the treatment of epilepsy, the three drugs used the best, can be Î² - The deposition of amyloid is reduced by more than 30%.

iPS cells are cells transformed by somatic cells such as skin cells and treated with an inducing factor. Their functions are similar to those of embryonic stem cells, and can be differentiated into various tissues and organs.

The team believes that the use of iPS cells and existing drugs for efficacy testing will hopefully develop safer Alzheimer's disease treatments. Relevant research results have been published in the online edition of the American Cell Report.

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