Nano red blood cells help photodynamic anti-tumor
September 20, 2018 Source: Health News
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Recently, Wang Dong, deputy director of the Department of Ultrasound, the First Affiliated Hospital of Chongqing Medical University, and Chen Yu, a team of researchers from the Shanghai Institute of Ceramics, Chinese Academy of Sciences, improved tumor tissue by constructing mitochondria-targeted “Nano-RBCâ€. Breakthroughs have been made in the study of hypoxia and photothermodynamics and anti-tumor effects. The relevant results papers were published in the famous international academic journal SCI 1 magazine "Advanced Science", and team member Zhang Liang was the first author of the article.
It is understood that in the early stage of the tumor, due to the mismatch between angiogenesis and excessively rapid tumor cell proliferation, the tumor is in a hypoxic environment, stimulating the release of hypoxia-inducible factors. Therefore, not only will the sensitivity of the tumor to radiotherapy and chemotherapy be reduced, but also the formation of tumor neovascularization will be induced, thereby inducing recurrence, invasion and metastasis of the tumor cells, which is an important reason for the tumor to be cured.
"Tumor tissue hypoxia is a major feature of solid tumors. This phenomenon will reduce the killing ability of photodynamic therapy and other tumors. The mitochondria-targeted artificial nano-red blood cells will be the photodynamic combined photothermal therapy for tumor oxygen intervention. A new idea is coming." Wang Dong introduced that the research group used a phospholipid layer similar to the erythrocyte membrane to encapsulate the photosensitizer and oxygen carrier (PFOB) complex, and constructed a "nano artificial red blood cell" with oxygen and oxygen release functions. Targeted mitochondrial enrichment. The photoacoustic imaging of oxyhemoglobin found that "nano artificial red blood cells" can directly transfer oxygen to the interior of the tumor and improve the hypoxia of the tumor tissue.
It is reported that this nano red blood cell has the functions of enhancing photoacoustic imaging, CT imaging and fluorescence imaging, and can be used as a contrast agent for various imaging modes to monitor the enrichment of nano red blood cells in the tumor area, guide treatment and monitor the therapeutic effect. Under the excitation of near-infrared laser, the photosensitizer converts light energy into heat energy, which produces photothermal therapy effect. In addition, a large amount of oxygen molecules carried by nano artificial red blood cells and photosensitizers "burst" to produce a single line killing effect on tumor cells. Oxygen enhances the effects of photodynamic therapy. The mitochondria are very sensitive to high temperature and singlet oxygen. The targeting effect of mitochondria enhances the therapeutic effect of photothermal and photodynamics, and achieves image-guided and efficient tumor photodynamic combined photothermal therapy. (Special correspondent Yu Fang Chen Ying)
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