Recently, a research report published in the international magazine Molecular Cell, researchers from the Darmstadt University of Technology found that the process of repairing DNA damage may be much more complicated than we think, DNA double The broken end structure of the chain may not be as simple as adding it, it will first undergo a fine change so that the original genetic information can be stored.
As a carrier carrying genetic information, DNA is prone to sustained damage. The most serious damage is DNA double-strand break, and the double helix structure is divided into two. If the DNA damage in the cell cannot be eliminated If it is repaired, important genetic information will be lost. This will lead to cell death, or induce permanent genetic changes and cell transformation. As the human body evolves, the method of repairing DNA damage in the body will continue to innovate. In the DNA damage repair process, many enzymes work together to maximize the recovery of genetic information in DNA.
There are currently two methods for repairing DNA double-strand breaks, which differ in accuracy and complexity. One of the simplest methods is non-homologous end joining, which is as fast as possible. The two ends of the break are connected, but this method does not focus on restoring the genetic information of the damage accurately; the second method is homologous recombination, which can utilize the exact same inheritance in the sister copy. Information to repair damaged DNA with high accuracy. However, progeny copies such as these will only be present in dividing cells, and genetic information will be replicated before cell division.
Image courtesy of watchdog. Org
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