Drugs for treating osteoporosis or treating breast cancer
May 08, 2018 Source: Xinhuanet
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Professor Dong Chenfang from Zhejiang University School of Medicine in China recently discovered that zoledronic acid, which is used to treat osteoporosis, can effectively inhibit the spread and metastasis of basal cell-like breast cancer, and is expected to become a target for the treatment of this malignant tumor. drug. Related research results were published in the new issue of the American Journal of Experimental Medicine.
According to data from the Chinese Society of Clinical Oncology, breast cancer has become the most common malignant tumor in women worldwide. Among the four clinical subtypes of breast cancer, basal cell-like breast cancer is highly invasive, and tumor cells lack the therapeutic targets of estrogen, progesterone receptor and epidermal growth factor receptor 2, and the prognosis is better than other breast cancers. Subtype is poor.
After analyzing more than 5,000 breast cancer cases, Dongchen Fang's research group found that a basal cell-like breast cancer cell, a metabolic enzyme "uridine diphosphate glycosyltransferase 8" (UGT8) is extremely active and can produce a large amount of glucosinolates. Lipid, while sulfatide activates signaling pathways for cancer cell survival and metastasis. Mouse experiments have shown that the effect of zoledronic acid on tumor cells is similar to that of direct knockout of UGT8, which has a similar mechanism to regulate cell metabolism and function.
Dong Chenfang told Xinhua News Agency that zoledronic acid has been used to treat osteoporosis, and its mechanism may be related to the inhibition of osteoclast activity. It is now found to be a direct inhibitor of UGT8, which can inhibit the invasion and metastasis of tumor cells. . As a safe market-based drug, it is expected to be a targeted drug for the treatment of basal cell-like breast cancer. (Reporter Zhou Zhou)
I. Introduction
Papermaking dry strengthen agent is our company`s new and self-developed products that using imported raw materials. Its mechanism of action is: dry strength agent use polymer mesh structure to increase hydrogen bonding number in the mutual area of fiber to fiber. Dry strength agents in the combination area of long-chain polymers can be deformed, thus increasing the bond toughness. It could improve paper strength by the bridging ability formed by chemical function to make fibers and fibers have "implicated"
II. Technical indicators
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Name |
Dry strength agent |
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Appearance |
Colorless viscous liquid |
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Solid content% |
15%±1% |
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Viscosity mpa.s(25℃) |
3000-13000 |
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PH value |
3.5-5.0 |
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Storage period (normal temperature) days |
3months |
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Note: PH value is adjustable according to user requirements |
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III. Function
The dry strength agent is not only a good enhancement, but it also has a higher enhancement effect in waste papers with more fine fiber filler. The use of our dry strength agent can improve paper quality, and it also significantly increase production efficiency, reduce costs and increase economic efficiency.
IV. Method of Application and Notes
1. When diluted with clean water, the dilution multiples of our product is generally about 15 to 30 times. After the product was stirred sufficiently, add uniformly to the slurry in an amount of 5 ~ 10 kg / ton.
2. Adding position that selected could have a full contact with the slurry. Generally choose ingredients pool, high box or import pump.
3. Use a plastic or stainless steel as the material for products storage, dilution tank, piping etc.. Iron-based material will produce corrosion and thickening phenomenon will occur.
4. Do not mix with Other Chemicals.
V. Packing
1000 kg barrels, or according to user requirements.
Dry Strength Agent,DSR,Dry Strength Additive,Chemicals Dry Strength Agent
Shandong Tiancheng Chemical Co., Ltd. , https://www.tianchengchemical.com