According to a neuroscience study recently published online by Nature magazine in the United Kingdom, a team of American scientists discovered that the level of protein phosphorylation in the brain may drive sleep desire. The study reveals the molecular basis of sleep needs and highlights potential molecular targets for sleep-related therapies. At the same time, it also allows people to take a step closer to revealing the mystery of sleep.
The circadian rhythm can make us perceive the change of the environment caused by the rotation of the earth and ensure our sleep, but this does not explain why humans need sleep. The theory holds that sleep can regulate the connection strength of neurons. Drosophila experiments have shown that sleep has a close relationship with its neuronal activity. Drosophila which has been deprived of sleep for a long period of time has a consistent reduction in its ability to respond to repeated stimuli. However, the molecular basis of this sleep demand remains unknown. Moreover, although fruit flies and mammals share a common basal sleep feature, this is still not confirmed in mammals.
Scientists previously believed that in mammals, the so-called "sleep-wake" cycle should be driven by a homeostatic mechanism that balances sleep needs and actual sleep time. In view of this, the research team of the University of Texas Southwestern Medical Center analyzed brain protein phosphorylation levels in sleep deprivation and Sleepy mutation mouse models. In the study they found that overall phosphorylation levels correlated with sleep needs. Sleep reduces phosphorylation levels, whereas prolonged arousal results in hyperphosphorylation and high sleep needs.
The team identified 80 proteins (mainly synaptic proteins) whose phosphorylation status changed according to sleep needs. The researchers said that this is very thought-provoking because synaptic plasticity is also related to sleep. According to the synaptic balance hypothesis, sleep gives synapses the opportunity to recover from their daily activities and maintain a balance. Therefore, phosphorylation of synapsin may be the key to maintaining synaptic balance and "sleep-wake" balance.
Viral Transportation Medium Tube
Uses: used for the detection and sampling of influenza, hand, mouth, foot and other epidemic diseases
Inspection principle:
The combination of multiple antibiotics has broad-spectrum antibacterial and antifungal effects;
As a protein stabilizer, bovine serum albumin can increase the survival time and infection stability of the virus;
Buffers such as Hank's build a neutral environment, which helps to increase the survival time and infection stability of the virus;
Phenol red is an acid-base indicator, the discoloration area is 6.6 (yellow)~8.0 (red), and it is red at 7.2~7.4.
Steps:
1. According to the sampling requirements, use a sampling swab to collect samples.
2. Place the swab after collecting the sample into a sterile sampling tube.
3. Break the sampling swab rod that is higher than the sterile sampling tube.
4. Tighten the cap of the sterile sampling tube.
5. Label the sterile sampling tube with information as required.
For sample collection, transportation and storage.
Product advantages:
1. The virus discretion of the flocking swab is high to ensure the accuracy of the test results.
2. The samples are well sealed to ensure product transportation and safe storage.
3. Product instruction manual, product certificate
Product Details:
1. The product set includes a one-time Virus Sampling Tube (including preservation solution), a self-sealing bag, a sampling swab, and instructions.
2. Product specification: 100 sets/box, 8 boxes/box 3. Product weight: 0. 65kg/box, 13. 2kg/box
4. Packing size: 25. 5*23. 5*14. 5 boxes, 53*49*32/carton
Scope of application:
Work resumption testing, the best choice for large-scale population screening
Features:
1. Transport at room temperature, stably preserve viral RNA
2. Pre-packaged guanidine salt lysate can inactivate the new coronavirus, ensuring the safety of transportation and testing personnel 3. The large-capacity preservation solution can fully soak the swab head,
The sample size can be divided into three parts for testing and reserve samples respectively to meet the testing needs.
Scope of application:
Suspected cases, disease control testing, preferred by P3 laboratory
Viral Transportation Medium Tube,Sample Collection Tubes,Transport Nasal Swab With Tube,Virus Sampling Tube Nasopharyngeal Swab
Jilin Sinoscience Technology Co. LTD , https://www.jilinsinoscience.com