The team of experts from the Harbin Institute of Veterinary Research of the Chinese Academy of Agricultural Sciences, a team of experts in zoonotic and virulent alien diseases, has made new advances in the mechanism of the replication cycle of the Japanese encephalitis virus and revealed for the first time the secret of the involvement of host factor SPCS1 in the assembly of Japanese encephalitis virus. Related academic results have been published online in the internationally renowned professional journal Virology.
The Japanese encephalitis virus and dengue virus, West Nile virus and Zika virus belong to the genus Flaviviridae. They are mainly pigs in nature and are transmitted by mosquitoes. They mainly occur in Asia and the Western Pacific. Continuing threats to animal and human health continue to trigger new epidemics and public health crises. In-depth exploration of the pathogenic mechanism of this virus, explaining the mechanism of regulation of each link in the virus replication life cycle, will help provide a theoretical basis for the development of new antiviral drugs and therapeutic strategies.
Harbin Veterinary Research Institute research team Huarong Hong, Bu Zhigao, Ma Le et al. used the Japanese encephalitis virus as a model to use RNA interference technology and knockout cell line technology to verify and confirm that the host factor SPCS1 participated in the regulation of virus replication. The SPCS1 molecule was found to interfere with the assembly of viral particles in addition to the shear processing of viral polyproteins. Further studies have shown that SPCS1 interacts with the Japanese encephalitis virus NS2B protein and that the interaction is concentrated on the two transmembrane domains of the NS2B protein and the C-terminal fragment of the SPCS1 molecule that contains the transmembrane domain.
At present, there is no international market for specific drugs for the treatment of Japanese encephalitis. Experts in the industry commented that the above research improved and outlined the details of the mechanism of the life cycle of yellow virus infection such as Japanese encephalitis, deepened the understanding of the interaction between host factors and viruses, and provided new ideas for the development of new antiviral drugs in the future. direction. (Reporter Yi Xiaofeng)
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