Recently, a team of scientists from the University of California, San Francisco published a new report in the journal Nature entitled "The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors." They first confirmed that the lung is a hematopoietic organ, animal. More than half of the platelets in the body are from the lungs, something that has never been seen before.
The head of the paper, Professor Mark Looney of the University of California, San Francisco, said: "This discovery undoubtedly illustrates the complex role of the lungs - they are not only used for breathing, but also important participants in the generation of key components of the blood, we The results observed in mice strongly suggest that the lungs also play a key role in human blood production." For millions of patients with blood diseases and patients requiring lung transplantation, this new finding It may have a huge and far-reaching impact on the treatment of their disease.
Mark R. Looney, MD
It is understood that the biggest player behind this breakthrough research is a technology called two-photon intravital imaging. Professor Looney is one of the co-inventors. This imaging technology enables researchers to Extremely fine observations were made to see the behavior of individual cells in the tiny blood vessels of the lungs of living mice.
Two-photon in vivo imaging imaging process
Initially, Looney and his team used this technique to investigate the role of the lung's immune system and circulating platelets. They used mice that were engineered to produce bright green fluorescence. Surprisingly, scientists have observed an amazing number of platelet-producing cells, megakaryocytes, in the blood vessels of the lungs. Although such cells have previously been observed in the lungs, they are generally thought to "live" primarily in the bone marrow, producing platelets.
In the lungs, there are many cells that reach platelet factor 4 (PF4) (red) (Source: Nature)
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