A brief introduction to the influencing factors of high-speed mixing granulation mechanism

Generally speaking, the particles made by the high-speed mixing granulator are irregular in shape, uniform in particle size distribution, and the structure is better than other traditional granulation processes, but the granulated finished product involves many factors, and its influence is now simplified. Said.

1. The influence of the stirring paddle and the cutting knife speed

It can be said that the size and distribution of the particle size are directly related to the rotation speed of the stirring paddle and the cutting blade. When the cutting speed is slow, the particle size becomes larger, while the rotating speed is faster, the particle size becomes smaller; when the stirring paddle rotates slowly, the particles The particle size is small, and the particle diameter is large as the rotation speed is fast, and the two functions are opposite.

2. Effects of mixing, granulation procedures and time

Because in the operation of the high-speed mixing granulator, the rotation of the stirring paddle causes the material in the pot to roll to the space, so that the material of the bottom of the pot is thrown along the wall of the pot. This action pushes the soft material to the quick cutting knife one by one, and is The particles are cut into different sizes, and are rounded and gradually spherical as the particles roll over each other for a while. It can be seen from the above that the speed and time of the stirring paddle and the cutting blade affect the particle size of the granulation.

3. Influence of materials and concentration

In wet mixed granulation production, alcohol granulation or dextrin binder is commonly used for granulation, and the adhesion of the two is somewhat different. It is common to use alcohol to make granules. The granules are small and fine, and easy to dry. This is because alcohol does not have viscosity, and it has a loose effect. It is ideal for granulation of Chinese medicine with high viscosity. When the paste is used to refine the granules, the granules produced are large and coarse, and the drying is slow. This is because the dextrin is sticky and has a polymerization effect, and the medicinal preparation having no viscosity is preferable.

In addition, whether it is diluted with concentrated extract as a material or a material using dextrin or other binder, when producing smaller particles, the slurry concentration of the material can be thinner. When larger particles are required, the material is The slurry concentration can be slightly stronger.