Scientists discover new ways to grow hematopoietic stem cells
May 03, 2016 Source: Bio Valley
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Researchers at the McMaster University's Stem Cell and Cancer Research Institute have made significant advances in understanding the stem cells of the human blood system, and they have discovered how a key protein allows these cells to better control and regeneration.
The study, recently published in the journal Nature, illustrates how a protein called Musashi-2 regulates the function and development of important hematopoietic stem cells.
The study found new strategies that can be used to control the growth of these stem cells. These cells can be used to treat a range of deadly diseases, but they are often in short supply.
The research's senior author, Kristin Hope, is a Principal Investigator at the Stem Cell and Cancer Institute and an Assistant Professor in the Department of Biochemistry and Biomedical Sciences at McMaster University. Other collaborators include researchers from the University of California, San Diego, the University of Toronto, and the University of Montreal.
Hope said the findings could have profound effects on thousands of patients suffering from a range of blood diseases, including leukemia, lymphoma, aplastic anemia, and sickle cell disease.
"We have actually clarified how these stem cells work. It is now possible to understand how they work at a whole new level, which provides us with a huge advantage in determining how to maximize the use of these stem cells for therapy. The newly discovered control of these cells The ability to regenerate will enable more patients to get the treatment they need."
The research team specifically studied stem cells from cord blood. Cord blood is a proven but less utilized source of stem cells for treating adult blood cancer. These stem cells have the potential to become important therapies for the treatment of thousands of blood cancer patients awaiting life-saving transplantation.
Cells from cord blood have unique properties that make them easier to use for transplantation, including availability and adaptability. Therefore, they allow for a safer and more efficient porting.
Hope pointed out that the problem is that there are very few stem cells available in individual cord blood samples - only 5% of all samples actually contain enough cells for transplantation. The team's in-depth study of the importance of Musashi-2 and its role in amplifying the number of stem cells in a given blood sample may help alleviate current stem cell shortages.
Gene Yeo, co-author of the study and associate professor at the University of California, San Diego, added: "Most stem cell research focuses on proteins that bind to DNA to control gene export. (But) Musashi-2 binds to RNA, which we found. The prominent role of protein also emphasizes the urgent need to study the regulation of this second level of genes in stem cells."
Hope said: "Providing more stem cells for transplantation may alleviate some of the current post-transplant complications and allow faster recovery (patients), which in turn reduces overall medical costs and waiting time for newly diagnosed patients seeking treatment."
"By expanding the number of stem cells, as we have done, more donated samples can now be used for transplantation."
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