Release date: 2016-03-18
For decades, scientists have had a headache in finding a way to treat diabetes instead of injecting insulin. One of the main goals is to find ways to transplant healthy Beta-cells (ie, cells that are responsible for insulin production in diabetic patients). However, immune rejection has been the most serious problem since transplantation.
Now scientists have found an easier way: they created a synthetic paste. This paste delivers insulin to the patient through the skin. Therefore, it is no longer necessary to use injection or the like.
This new product has not been tested at the human level, but it has been shown in mice that the patch maintains blood glucose levels in mice for at least 10 hours.
Prior to this, the same research group released a similar insulin patch, and this new development is an upgraded version on top of this. This upgraded patch contains active beta cells, which means it keeps patients' blood sugar levels longer.
In addition, because beta cells are present in the patch, they are not attacked by the human immune system.
"The study found a treatment that evades the rejection of the autoimmune system, which is the desire to find ways to inhibit beta cells in routine research," said Zheng Gu, a principal investigator at the University of North Carolina. It proves that we can bridge the body between physiological signals. These in vitro cells can effectively maintain blood sugar levels in the body."
Beta cells are mainly found in the pancreas, and the insulin they release can help treat excess blood sugar in the blood after eating. In diabetic patients, such cells are damaged or unable to produce enough insulin. Therefore, it is necessary to continuously inject insulin into diabetic patients in conventional treatment.
This new type of paste primarily connects viable beta cells to the in vivo system through tiny pinholes. These pinholes are small and therefore do not cause pain to the human body.
These tiny needles connect the beta cells to the human blood system and are sensed by a device called a "glucose signal amplifier," which receives the signal and then secretes insulin.
This type of patch has been validated in mice with type 1 diabetes, which are able to respond quickly to sudden increases in blood sugar. The maintenance time is up to 10 hours.
This method is not only quick and convenient but also safer than conventional insulin treatments. The dose of conventional insulin injection is difficult to control and can cause many negative effects.
However, before you are in high spirits, this product has a long way to go before going public. At least the product needs to be verified at the human level. Because of the vast amount of evidence that shows its superiority to traditional methods of treating diabetes, this is indeed what we need in the future.
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"Scientists have created a painless patch that can control diabetes without injections"
Source: Bio Valley
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