For prostate cancer, complex genomic recombination events are a very common phenomenon. However, previous research has not solved this problem well. For second-generation sequencing (NGS) technology, detecting genomic structural variations with fragment lengths greater than 1 kb presents certain challenges. Next generation mapping technology can complement NGS and solve the problem of large genome fragment variation.
A few days ago, Australian researchers completed the world's first prostate cancer genome-wide mapping by combining NGS and NGM technology (based on Bionano Genomics' Irys system), providing new insights into further understanding of the disease. The study selected a prostate cancer sample with a standard Gleason score of 7 points, which is the most common diagnosis, but is highly unpredictable in the clinic.
The study revealed previously undetected DNA changes associated with the disease, and the results were published in the journal Oncotarget. Information obtained through genome-wide mapping of prostate cancer can be used to describe an individual's tumor characteristics and reveal previously unrecognized information, thereby making the treatment of the disease more targeted.
The large-scale DNA rearrangement event found in this study was 10 times higher than previously discovered, and 15 new potential drivers of prostate cancer were discovered.
Professor Vanessa Hayes, Garvan Medical Institute
The research director, Professor Vanessa Hayes of the Garvan Medical Institute, said, “Although we have been studying prostate cancer for many years, we have limited understanding of the drivers of these tumors. One of the biggest challenges in the clinic is to distinguish which cancers will spread and endanger. Life, which cancers can avoid damage to larger clinical treatments. For targeted therapy, we first need to understand the driving genes of each tumor."
Using a combination of new NGM technology and whole-genome sequencing, the researchers revealed the most comprehensive genome-wide map of prostate cancer to date.
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