Researchers from Ohio State University have found that although cancer is more likely to develop in diabetic patients, it is rare for patients with glioma, a brain tumor, to appear in high blood sugar and diabetes. Why?
The latest article in the journal Scientific Reports is based on the findings of a previous study by the Judith Schwartzbaum team at Ohio State University (hyperglycemia seems to reduce the risk of meningioma). "Diabetes and elevated blood sugar increase the risk of cancer in several parts, including the colon, breast, and bladder, but in this case, people with normal blood sugar are at higher risk than those with higher blood sugar or diabetes." Schwartzbaum said.
"Our research raises some new questions and answers them to better understand the molecular mechanisms of glioma development," she added.
Glioblastoma evolves from the deterioration of neuroepithelial cells and is the most common malignant tumor in the adult central nervous system. The mortality rate is extremely high. The malignant glioma has a 5-year survival of only 5%. It has invasive growth, easy recurrence, and prognosis. Poor and other characteristics. According to the WHO morphological classification criteria, gliomas are divided into four grades and multiple types. The degree of malignancy is different. The prognosis of conventional chemoradiotherapy is different. Different types and molecules of primary and recurrent gliomas develop. The mechanism is also different, so it is urgent to develop new classification standards for molecular pathology, to guide clinical treatment and individualized medical treatment , and to improve the survival and quality of life of patients.
The latest paper includes data from two long-term studies. The project, called AMORIS, involved 528,580 Swedes. The second project, Me-Can, consisted of 269,365 Austrians and Swedes, with a total of 812 participants with glioma.
Schwartzbaum et al. evaluated blood glucose and diabetes data, as well as subsequent brain cancer development, and found that patients with elevated blood glucose and diabetes had a lower risk of developing glioma.
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