Release date: 2017-03-20
People of the same age may look younger or older, and a recent study from the Columbia University Medical Center shows that the same is true for human brains, which can accelerate the brain aging of some people for 12 years. The study was published in the Cell magazine, Cell Systems.
Although their study does not specifically target neurodegenerative diseases such as Alzheimer's disease, this study may help develop a novel biomarker for assessing the effects of anti-aging treatments and at the same time becoming relevant for treating aging. The drug target of the disease.
The team looked at 1904 samples from the brains of older people without neurodegenerative diseases. They first tested the transcriptome of each sample—the initial product of gene expression, and then compared it with the average transcriptome of peers. Find mutants that increase the "difference" age. This difference means that people of the same age may have brains of different physiological ages.
“There is a mutant that stands out: TMEM106B,†said Dr. Herve Rhinn, an assistant professor at the University of Columbia's Taub Institute, one of the leading researchers. “This is very common. About one-third have two copies, another three points. One of the people has a copy."
The frontal cortex of a person with two copies of the wrong gene will be 12 years older than a person with two normal copies, said Professor Asa Abeliovich, one of the leading researchers and also from the Taub Institute. The frontal cortex is responsible for advanced brain activities, including memory, thinking, and emotions.
â–² Dr. Herve Rhinn from the University of Columbia's Taub Institute (Source: Columbia University Taub Institute)
â–² Professor Asa Abeliovich of the University of Columbia's Taub Institute (Source: Columbia University Taub Institute)
“TMEM106B will start to work around the age of 65,†Professor Abeliovich said. “At that time, people who were at the same stage would change because of some undefined pressure. If you have two normal copies, you can Deal with this pressure well. But if you have two bad copies, your brain will age faster."
Some studies suggest that certain genes increase the risk of a person with a neurodegenerative disease, such as ApoE, which increases the risk of Alzheimer's disease. "But these genes only explain a small part of these diseases," Dr. Rhinn said. "So far, the main cause of neurodegenerative diseases is aging. With aging, changes in the brain make you more susceptible to certain Brain disease."
Reference material
[1] Genetic variant can speed brain aging by up to12 years
[2] Brain-aging gene discovered
Source: WuXi PharmaTech (Wei Signal WuXiAppTecChina)
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